CancerSpeak: A podcast from CANCER, a journal of the American Cancer Society

Low-Grade Gliomas: Evolving Approaches to Care

Dr. Priya Kumthekar, Neuro-Oncology Section Editor for CANCER, and Dr. Helen Shih, Radiation Oncology Section Editor for CANCER, discuss the current treatment landscape for low-grade gliomas with a focus on the evolving role of isocitrate dehydrogenase (IDH) inhibitors. Drawing on findings from the INDIGO trial, they reflect on how recent evidence has informed ongoing discussions around the use of IDH inhibitors, alongside their perspectives on treatment planning and real-world clinical considerations. The conversation also emphasizes the importance of engaging patients in shared decision making throughout the course of care. 
Drs. Kumthekar and Shih invite investigators in neuro-oncology, radiation oncology, and related disciplines to consider submitting their research to CANCER. Their closing remarks highlight the journal’s global reach, supportive editorial staff, and connection to the mission of the American Cancer Society. 
Learn more about submitting your work to CANCER: https://acsjournals.onlinelibrary.wiley.com/journal/10970142/homepage/why-submit  
Original music by J.Gilman. 
Follow CANCER on social media: x.com/JournalCancer instagram.com/acsjournalcancer linkedin.com/company/acs-journals 

Innovations in Colorectal Cancer Screening: Advances in Noninvasive Testing

Dr. Christopher Li, editor of the Cancer Prevention and Epidemiology sections for CANCER, speaks with Dr. William Grady of Fred Hutchinson Cancer Center about the latest innovations in noninvasive colorectal cancer screening. Their conversation draws on highlights from Dr. Grady’s latest commentary in CANCER’s Top Advances of the Year series, exploring how emerging stool- and blood-based testing approaches are improving early detection, patient participation, and screening accessibility.
Read the commentary “Top advances of the year: Noninvasive colorectal cancer screening tests” here: https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.70115
Read more articles in CANCER’s Top Advances of the Year series: https://acsjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0142.top-advances-of-the-year
Follow CANCER on social media:x.com/JournalCancerinstagram.com/acsjournalcancerlinkedin.com/company/acs-journals
Original music by J. Gilman.

ASCO 2025 Recap: Advancing Cancer Research and Care

CANCER Editor-in-Chief Dr. Suresh Ramalingam is joined by Dr. Gil Morgan, Dr. Sandip Patel, and patient advocate Allison Rosen to reflect on key takeaways from the 2025 American Society of Clinical Oncology (ASCO) annual meeting. The discussion highlights notable clinical trials presented at the meeting, the emerging role of AI in the clinic and in research, and patient-centered perspectives on where the field is headed.Interested in submitting your work to CANCER? Learn more about our submission benefits, such as Free Format Submission and Direct to CANCER, here: https://acsjournals.onlinelibrary.wiley.com/hub/journal/10970142/homepage/forauthors.htmlFollow CANCER on social media:x.com/JournalCancerinstagram.com/acsjournalcancerlinkedin.com/company/acs-journalsOriginal music by J. Gilman.

CancerSpeak Mini Episode 4: New Guideline for Peritoneal Mesothelioma Management

Dr. Samuel Butensky and Dr. Elizabeth Godfrey briefly discuss the article “Consensus Guideline for the Management of Peritoneal Mesothelioma,” which introduces updated clinical guidance for this disease. This article is part of a series published jointly in Cancer and Annals of Surgical Oncology entitled “Consensus Guidelines for the Management of Peritoneal Surface Malignancies.”
🔗 Read the full article in Cancer: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.35868
📖 Explore all articles from the series: https://acsjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0142.PSM-consensus-guidelines
Music by Ivymusic from Pixabay.

CancerSpeak Mini Episode 3: Updated Approaches to Appendiceal Tumors With Peritoneal Involvement

Dr. Elizabeth Godfrey is joined by Drs. Michael White and Mustafa Raoof to discuss “Consensus Guideline for the Management of Patients with Appendiceal Tumors, Part 2: Appendiceal Tumors With Peritoneal Involvement.” This article is part of a series published jointly in Cancer and Annals of Surgical Oncology entitled “Consensus Guidelines for the Management of Peritoneal Surface Malignancies.”
🔗 Read the full article in Cancer: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.35874
📖 Explore all articles from the series: https://acsjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0142.PSM-consensus-guidelines
Music by Ivymusic from Pixabay.

CancerSpeak Mini Episode 2: New Guidance for Appendiceal Tumors Without Peritoneal Involvement

Dr. Elizabeth Godfrey, lead author of “Consensus Guideline for the Management of Patients with Appendiceal Tumors, Part 1: Appendiceal Tumors Without Peritoneal Involvement,” is joined by Drs. Michael White and Mustafa Raoof to discuss the updated clinical approach to this disease. This article is part of a series published jointly in Cancer and Annals of Surgical Oncology entitled “Consensus Guidelines for the Management of Peritoneal Surface Malignancies.”
🔗 Read the full article in Cancer: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.35867
📖 Explore all articles from the series: https://acsjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0142.PSM-consensus-guidelines
Music by Ivymusic from Pixabay.

CancerSpeak Mini Episode 1: Gastric Cancer With Peritoneal Metastases

Dr. Samuel Butensky, lead author of “Consensus Guideline for the Management of Gastric Cancer with Synchronous Peritoneal Metastases,” is joined by Dr. Brian Badgwell and Dr. Maheswari Senthil to highlight key updates to the 2018 Chicago Consensus guideline and clinical pathway. This article is part of a series published jointly in Cancer and Annals of Surgical Oncology entitled “Consensus Guidelines for the Management of Peritoneal Surface Malignancies.”
🔗 Read the full article in Cancer: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.35870
📖 Explore all articles from the series: https://acsjournals.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0142.PSM-consensus-guidelines
Music by Ivymusic from Pixabay.

The VOICES of Black Women Study: Expanding Representation in Cancer Research

Black women have long been underrepresented in large-scale cancer studies, leaving critical gaps in our understanding of the factors influencing cancer risk and outcomes. The VOICES of Black Women Study, launched by the American Cancer Society, is leading efforts to close these gaps by examining a range of health and social determinants to better understand their impact on cancer and other health conditions experienced by Black women. 
In this episode of CancerSpeak, Cancer Disparities Research Section Editor Dr. Camille Ragin speaks with Dr. Lauren McCullough, one of the study’s principal investigators and the lead author of a newly published editorial in Cancer that explores the rationale behind the VOICES study and its potential to drive meaningful change in cancer prevention and care. 
Read Dr. McCullough’s editorial in Cancer: https://bit.ly/VOICESofBlackWomenEditorial  
Learn more about the VOICES of Black Women study: https://bit.ly/VOICESofBlackWomenInfo 
Explore the American Cancer Society report “Cancer Statistics for African American and Black People, 2025” referenced in this episode: https://bit.ly/AAandBPStats2025  
Music by Ivymusic, obtained from Pixabay.  

The Power of Social Capital: Tackling Gender Inequalities in Academic Medicine

In this episode of CancerSpeak, host Dr. Ruth O’Regan, Deputy Editor and Breast Disease Section Editor of Cancer, is joined by Dr. Jennifer Grandis of the University of California San Francisco to discuss her team’s recent review article in Cancer on gender disparities in academic medicine. Tune in for a fascinating conversation between Dr. O’Regan and Dr. Grandis that explores how social capital and networking inequalities shape career advancement, the critical role of sponsorship, and strategies to create a more inclusive professional landscape.
Read Dr. Grandis’s article: https://bit.ly/SocialCapitalAndNetworking 
Music by Ivymusic, obtained from Pixabay.

CHIP, mCAs, and Cancer Risk: What We’re Learning

CANCER Section Editor and Host Dr. Courtney DiNardo welcomes Dr. Pinkal Desai, Dr. Koichi Takahashi, and Ms. Nehali Shah to discuss new research on the impact of clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) on the risk and mortality of solid tumors like breast, lung, and colorectal cancer. Dr. Desai highlights findings from her recent study published in CANCER, while Dr. Takahashi and Ms. Shah share perspectives from their accompanying editorial. The episode explores the potential impact of these findings on clinical care and future research directions.
Read Dr. Desai’s article: https://bit.ly/CHIPandmCAsonSolidTumorRisk
Read the editorial by Dr. Takahashi and Ms. Shah: https://bit.ly/CHIPandmCAsEditorial
Music by Ivymusic, obtained from Pixabay.